Hypertonic glucose inhibits growth and attenuates virulence factors of multidrug-resistant Pseudomonas aeruginosa

摘要: Pseudomonas aeruginosa is the most common Gram-negative pathogen responsible for chronic wound infections, such as diabetic foot and further exacerbates treatment options cost of conditions. Hypertonic glucose, a commonly used prolotherapy solution, can accelerate proliferation granulation tissue improve microcirculation in wounds. However, action hypertonic glucose on bacterial pathogens that infect wounds unclear. In this study, we investigated inhibitory effects multidrug-resistant P. strains isolated from infections. represents novel approach to control infections caused by aeruginosa. Four clinical ulcers tertiary hospital China reference PAO1 strain were studied. significantly inhibited growth, biofilm formation, swimming motility PAO1. Furthermore, reduced production pyocyanin elastase virulence factors The expression major quorum sensing genes (lasI, lasR, rhlI, rhlR) all downregulated response treatment. Galleria mellonella larvae infection model, administration was shown increase survival rates infected (3/5). aeruginosa, well gene expression. Further studies investigate therapy should be considered treating