The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease.
作者： Richard Mayeux , Yaakov Stern , Ruth Ottman , Thomas K. Tatemichi , Ming-Xin Tang
关键词: Apolipoprotein E 、 Dementia 、 Genetic predisposition 、 Allele 、 Allele frequency 、 Internal medicine 、 Linkage disequilibrium 、 Medicine 、 Family history 、 Genetics 、 Odds ratio
摘要: Apolipoprotein E (APO-E) binds to the beta-amyloid peptide and is present in senile neuritic plaques Alzheimer's disease (AD). The epsilon 4 isoform of APO-E has been associated with both sporadic familial late-onset AD, implying a causal role. Among patients control subjects similar age, gender, ethnic group from New York City community Washington Heights-Inwood, we found that odds ratio (OR) for AD homozygosity APO-epsilon was 17.9 (95% confidence interval [CI], 4.6-69.8) heterozygosity 4.2 CI, 1.8-9.5) compared persons other genotypes. association stronger among (OR = 10.3; 95% 3.4-31.1) than those family history dementia first-degree relative 0.9; 0.1-13.5). between did not differ according age at onset ( or 65), but appeared vary across 3 groups investigated (black, Hispanic, white). Our data confirm support hypothesis allele either confers genetic susceptibility may be linkage disequilibrium another locus. Ethnic variability allelic frequency elderly warrants further investigation.
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sci-hub.se 参考文章(16)
N. L. Earl, L. H. Yamaoka, K. A. Welsh, J. L. Bebout, A. Heyman, W. Y. Hung, R. J. Bartlett, M. A. Pericak-Vance, A. D. Roses, P. C. Gaskell, C. M. Clark, C. A. Haynes, A. P. Walker, M. J. Alberts, Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. American Journal of Human Genetics. ,vol. 48, pp. 1034- 1050 ,(1991)
Jane A. Cauley, June E. Eichner, M. Ilyas Kamboh, Robert E. Ferrell, Lewis H. Kuller, Apo E allele frequencies in younger (age 42-50) vs older (age 65-90) women. Genetic Epidemiology. ,vol. 10, pp. 27- 34 ,(1993) , 10.1002/GEPI.1370100104
Stanley Lemeshow, David W. Hosmer, Applied Logistic Regression ,(1989)
A. M. Saunders, W. J. Strittmatter, D. Schmechel, P. H. St. George-Hyslop, M. A. Pericak-Vance, S. H. Joo, B. L. Rosi, J. F. Gusella, D. R. Crapper-MacLachlan, M. J. Alberts, C. Hulette, B. Crain, D. Goldgaber, A. D. Roses, Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology. ,vol. 43, pp. 1467- 1472 ,(1993) , 10.1212/WNL.43.8.1467
W. J. Strittmatter, A. M. Saunders, D. Schmechel, M. Pericak-Vance, J. Enghild, G. S. Salvesen, A. D. Roses, Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 1977- 1981 ,(1993) , 10.1073/PNAS.90.5.1977
R. Mahley, Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. ,vol. 240, pp. 622- 630 ,(1988) , 10.1126/SCIENCE.3283935
M. J. Ignatius, P. J. Gebicke-Harter, J. H. Skene, J. W. Schilling, K. H. Weisgraber, R. W. Mahley, E. M. Shooter, Expression of apolipoprotein E during nerve degeneration and regeneration Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 1125- 1129 ,(1986) , 10.1073/PNAS.83.4.1125
Robert E. Pitas, Janet K. Boyles, Susan H. Lee, Donna Foss, Robert W. Mahley, Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochimica et Biophysica Acta. ,vol. 917, pp. 148- 161 ,(1987) , 10.1016/0005-2760(87)90295-5
H. Toutenburg, Fleiss, J. L.: Statistical Methods for Rates and Proportions. John Wiley & Sons, New York-London-Sydney-Toronto 1973. XIII, 233 S. Biometrische Zeitschrift. ,vol. 16, pp. 539- 539 ,(1974) , 10.1002/BIMJ.19740160814
Yoshio Namba, Masanori Tomonaga, Hiroshi Kawasaki, Eiichi Otomo, Kazuhiko Ikeda, Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease Brain Research. ,vol. 541, pp. 163- 166 ,(1991) , 10.1016/0006-8993(91)91092-F