Development of Intestinal Intraepithelial Lymphocytes
作者： Leo Lefrançois , Barbara Fuller , Sara Olson , Lynn Puddington
DOI: 10.1016/B978-012394330-9/50017-X
关键词: Immune system 、 Neonatal thymectomy 、 Intraepithelial lymphocyte 、 Immunology 、 Dual role 、 Biology
摘要: Publisher Summary Intraepithelial lymphocytes (IEL) of the small and large intestine comprise a specialized immune compartment presumably geared toward surveillance intestinal epithelial layer. One most intriguing aspects IEL biology is role thymus in their development. This chapter utilizes neonatal thymectomy grafting as means studying In case grafting, it tested whether capable producing IEL, rather than asking removal affects maturation. Overall, results demonstrate that plays dual development: source precursors yet unidentified factors aid
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