Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline)
作者： Maarten Vergaelen , Bart Verbraeken , Joachim F. R. Van Guyse , Annelore Podevyn , Ali Tigrine
DOI: 10.1039/C9GC03872H
关键词: Organic chemistry 、 Solvent 、 Ring-opening polymerization 、 Acetonitrile 、 Polymerization 、 Chemistry 、 2-ethyl-2-oxazoline 、 Chlorobenzene 、 Ethyl acetate 、 Pollution 、 Environmental chemistry
摘要: Poly(2-ethyl-2-oxazoline) (PEtOx) is the most common poly(2-oxazoline) for biomedical applications resulting from its high water-solubility, good commercial availability and well-controlled polymerization. In this article, we report polymerization of 2-ethyl-2-oxazoline (EtOx) in ethyl acetate to replace current state-of-the-art EtOx acetonitrile chlorobenzene. This switch towards as green solvent an important improvement pharmaceutical compliance/compatibility, besides lower burden environment.
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