Thymic Tumor Progression in SV40T Transgenic Mice Model

摘要: Large T antigen of simian virus 40 (SV40 Tag) is a nuclear protein necessary to synthesize DNA and potent oncogene, determining both immortalization transformation multiple cell types not only in culture system but also vivo.1,2 Transgenic mice offer the potential for studying biological effects gene expression under physiological conditions that cannot be reproduced culture, thus providing may accurately emulate differentiated tissues behavior pathological processes, such as neoplastic transformation.3 mouse harboring SV40 Tag has been used an animal model spontaneous carcinogenesis by regulating its with variety trans-criptional elements. Choroid plexus tumor pancreatic islet tumors were developed most studies transgenic mice.4–10 In addition, large induced neoplasm i.e., lymphoma, rhabdomyosarcoma, osteosarcoma, stomach carcinoma, hepatoma, melanoma, retinoblastoma, or hibernoma,11–21 depending on transcriptional signals expression. Although thymic hyperplasia reported incidental findings mice, there no reports carcinoma mice. Thymic was observed incidentally some cases producing choroid tumors4,6,7,10 main event growth hormone-releasing factor(GRF) promoter fused antigen22,23. Recently Teitz et al24 mixed type thymoma expressing control erythroid specific enhancer. This first report frank epithelial Tag. Besides Tag, Thyl-myc complex lymphoid tumors.25