Corticosteroid hormone action in the cardiovascular system
作者： Fabian Hammer
DOI:
关键词: Glucocorticoid secretion 、 Corticosterone 、 Internal medicine 、 Hyperaldosteronism 、 Endocrinology 、 Aldosterone 、 Hormone 、 Essential hypertension 、 Spironolactone 、 Biology 、 Pharmacology 、 Mineralocorticoid receptor
摘要: The cardiovascular system (CVS) has emerged as an important target of corticosteroid hormones. Mineralocorticoid receptor antagonists provide protection and are now routinely used in disorders such primary hyperaldosteronism, resistant hypertension congestive heart failure (CHF) but the underlying molecular mechanisms hormone action remain unclear. We have characterised metabolism by 11β- hydroxysteroid-dehydrogenases (11β-HSDs) isolated adult rat cardiomyocytes (CM) cardiac fibroblasts (cFb). detected 11β-HSD1 expression activity CM cFb where it facilitates glucocorticoid action, whereas 11β-HSD2 was absent. shown differential gene regulation aldosterone (Aldo) corticosterone identified novel Aldo genes which may insights into action. also studied role corticosteroids essential effect spironolactone (Spiro) upon their secretion patients with chronic kidney disease. that mineralocorticoids not glucocorticoids involved elevated blood pressure Spiro treatment results compensatory activation renin-angiotensinaldosterone (RAAS), unchanged. In summary, these data clinical CVS.
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