作者: Noble Kuntworbe , Nataly Martini , John Shaw , Raida Al-Kassas
DOI: 10.1002/DDR.21010
关键词: Malaria prevention 、 Disease 、 Nanotechnology 、 Intervention (counseling) 、 Malaria 、 Antimalarial chemotherapy 、 Combination drug therapy 、 Medicine 、 Pharmacotherapy
摘要: In order to better understand the persistence of malaria, it is timely reflect on various approaches toward its eradication and consider what being done well identify needs be improved.This review explores currently available tools policies designed eradicate malaria potential difficulties associated with each. We have also considered pharmaceutical nanotechnology as a possible tool in fight against malaria. Each policy, ranging from adaption combination drug therapy deployment insecticide-treated nets was laudable. The implementation coverage policies, however, exposed many gaps disease. Some challenges identified include misdiagnosis, production distribution fake substandard antima- larial drugs, misapplication insecticides, poor infrastructure, lack sociopolitical will, conflicts leading displacement people. Failure has been attributed development multiple resistance side effects use conventional antimalarial chemotherapy. formulation strategy that improve safety efficacy help cause eradication. conclusion, this expected provide understanding each them. It suggests reduce drugs their should given serious attention. Drug Dev Res 73 : 167-184, 2012. © 2012 Wiley Periodicals, Inc.