Design and in vivo assessment of polyester copolymers based on trimethylene carbonate and ε‐caprolactone
作者： Chong Zhang , Danhua Liu , Xiaowei Zhang , Ping Wang , Zhu Zhen
DOI: 10.1002/APP.41815
关键词: Materials science 、 Caprolactone 、 Copolymer 、 Biocompatibility 、 Silicone 、 Nuclear chemistry 、 Polymer chemistry 、 Polyester 、 Silicone rubber 、 Compression molding 、 Trimethylene carbonate
摘要: Poly(trimethylene carbonate-co-caprolactone) (PTCL) copolymers with various trimethylene carbonate ratios were synthesized by ring-opening polymerization and used to prepare implants for an in vivo experiment. Medical silicone rubber was as the control. Implants prepared compression molding a laboratory instrument. The properties of these copolymer investigated. PTCL rubbers implanted subcutaneously dorsal region New Zealand white rabbits. assessment performed 1, 2, 3, 4, 5, 6, 7, 8 months postoperatively determination weight loss, water uptake, thermal behavior, molecular explanted implants, histological examination. During 8-month implantation, value maximum loss found be 25%. A continuous decrease occurred. No remarkable tissue reactions observed during degradation, foreign-body similar those rubbers, which are commercially available materials. In this study, we aimed indicate likely clinical behavior but good biodegradable compared rubber. This may open new avenue application them drug industry. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41815.
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