Facilitatory action of etomidate and pentobarbital on recurrent inhibition in rat hippocampal pyramidal neurons.

摘要: Biochemical studies have shown that the non-barbiturate anesthetic etomidate can interact in a stereoselective, barbiturate-like fashion with GABA/benzodiazepine receptor complex, enhancing both benzodiazepine and GABA binding, but its electrophysiological effects upon mammalian CNS are largely unknown. The present investigations were designed to characterize of on recurrent GABAergic inhibitory pathway CA1 region rat vitro hippocampal slice compare actions those pentobarbital. Electrical stimulation alveus elicited biphasic hyperpolarizing response, consisting an initial bicuculline-sensitive IPSP. This was followed by second component, termed late potential (LHP), which is thought reflect increase potassium conductance. Both pentobarbital (100 microM) (+)-etomidate (10 markedly increased duration GABA-mediated IPSP, frequently amplitude as well. However, no significant either these drugs observed LHP. Together previous biochemical findings, our data suggest depressant barbiturates nervous system may common action stereoselective site intimately associated receptors chloride ion channel.