Discriminative stimulus effects of dextrorphan in pigeons.

摘要: Pigeons were trained to discriminate between dextrorphan (10 mg/kg) and saline in a task which 20 consecutive key pecks on either the left or right key, depending whether had been administered, produced food. During sessions stimulus generalization other drugs was evaluated, responses dextrorphan- saline-appropriate Dextromethorphan dexoxadrol dose-related control of behavior similar that by dextrorphan. In contrast, l-isomers these compounds, levomethorphan, levoxadrol levorphanol, at doses up including those markedly decreased rate responding, responding primarily key. addition, both d- methadone, codeine, morphine, butorphanol profadol resulted predominantly responding. l-Cyclorphan, dl-, l- d-SKF-10,047 d-cyclazocine dextrorphan-appropriate whereas, l-oxilorphan (the 14-hydroxymorphinan analog cyclorphan), d-pentazocine, d-ethylketazocine l-naltrexone exclusively intermediate appropriate for Although levorphanol alone produce little no coadministration naltrexone (1.0 high but not levoxadrol, dextrorphan.(ABSTRACT TRUNCATED AT 250 WORDS)