Fucoxanthin in the management of obesity and its related disorders
作者： Kazuo Miyashita , Masashi Hosokawa
DOI: 10.1016/J.JFF.2017.07.009
关键词: Thermogenin 、 Insulin resistance 、 Adipokine 、 Brown adipose tissue 、 Thermogenesis 、 Internal medicine 、 Biology 、 Glucose transporter 、 Endocrinology 、 GLUT4 、 White adipose tissue
摘要: Abstract Interest in a novel biological agent fucoxanthin (Fx) has been growing recent years, which connects Fx to increases energy expenditure and implications for the management of obesity type 2 diabetes mellitus (T2DM). Several molecular targets offer most hope influencing expenditure. One keys success will be uncoupling protein 1 (UCP1). can reduce excess fat accumulation abdominal white adipose tissue (WAT), is primarily based on up-regulation thermogenesis through UCP1 expression both brown (BAT) WAT. down-regulates pro-inflammatory adipokines involved insulin resistance from WAT subsequently normalizes blood glucose level. In addition, promote utilization skeletal muscle by up-regulating transporter 4 (GLUT4) promoting its translocation cell membrane cytosol.
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