Terahertz Imaging and Electromagnetic Model of Axon Demyelination in Alzheimer's Disease
作者： Woon-Gi Yeo , Ogan Gurel , Nandhini Srinivasan , Paul D. King , Niru K. Nahar
DOI: 10.1109/TTHZ.2017.2739481
关键词: White matter 、 Nuclear magnetic resonance 、 Spectroscopy 、 Electromagnetic model 、 Axon demyelination 、 Materials science 、 Human brain 、 Postmortem brain 、 Reflectivity 、 Terahertz radiation
摘要: We investigate the utility of terahertz (THz) spectroscopy in identifying Alzheimer's disease human brain tissue. Using reflection-mode time-domain THz spectroscopy, two-dimensional images formalin-fixed and paraffin-embedded tissue samples hippocampus area were recorded 60 GHz-2 band. The compared with microscopic same after hematoxylin eosin staining. demonstrate that reflection spectra, particularly from white matter, reveal detectable differences between postmortem tissues exhibiting normal controls. reflectivity matter areas was on average 4.2% higher than gray regions known history, whereas for control contrast only 2%. Additional studies further enhance this hypothesis, demyelination suggests a possible cause spectra. also compare response conventional Luxol-fast blue staining to correlation two methods predicting demyelination. In addition, we present simplified electromagnetic model axons various degrees support hypothesis through full-wave simulations. This study offers, first time, proof concept feasibility detecting using ex vivo samples.
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