THE HEXOKINASE ISOZYMES: SULFHYDRYL CONSIDERATIONS IN THE REGULATION OF THE PARTICLE-BOUND AND SOLUBLE STATES
作者： HOWARD M. KATZEN , DENIS D. SODERMAN
DOI: 10.1016/B978-0-12-472702-1.50054-2
关键词: Oxidized Glutathione 、 Biochemistry 、 Chemistry 、 Isozyme 、 Electrophoresis 、 Incubation 、 Particle 、 Hexokinase 、 Catalysis
摘要: ABSTRACT. The presence in types I and II hexokinases of sulfhydryls required for catalysis was demonstrated by the inactivating effects N-ethylmaleimide (N.E.M.) p-chloromercuribenzene-sulfonate (PCMBS) on soluble isozymes. Interaction type with oxidized glutathione incubation intact tissues N.E.M. produced catalytically-active electrophoretic variants (I S ) I, indicating sulfhydryl(s) distinct from those supporting catalysis.
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