Hancornia speciosa: indications of gastroprotective, healing and anti-Helicobacter pylori actions.

摘要: Ethnopharmacological relevance: Mangaba (Hancornia speciosa Gomez) is a medicinal plant frequently cited in ethnopharmacological inventories of the central region Brazil against gastrointestinal disorders such as diarrhoea, ulcer, gastritis and stomachache. Aim study: The hydroalcoholic extract (HE) infusion (BI) Hancornia bark were investigated for their ability to prevent heal rodent gastric ulcer. Materials methods: preventive healing action both preparations evaluated experimental models rodents that simulated this disease human mucosa. Results: BI did not exert gastroprotective effect, contrast HE (500 mg/kg, p.o.) decreased (p < 0.05) severity damage induced by HCl/ethanol (52%), indomethacin/bethanechol (51%), stress (52%) or pylorus ligature experiments (54%). increased pH acid output juice. This promoted increase mucus amount (3.62 mg/wt. tissue vs. 5.81 tissue), (67%) displayed anti-Helicobacter pylori effect. Conclusions: antiulcer resulted formation antioxidant properties polymeric proanthocyanidins present composition plant.