Chemokines as modulators of neuroendocrine functions

摘要: Chemokines are small secreted proteins with chemoattractant properties for immune cells. Besides their role in the system, chemokines and receptors may play important roles central nervous system. Neurodegenerative disorders that involve neuroinflammation such as multiple sclerosis, stroke, Alzheimer's disease, Parkinson's disease HIV-associated dementia commonly associated local upregulation release of chemokines. However, recent work has established certain chemokines, constitutively expressed brain, exert functions brain distinct from inflammation. These regulate neuronal migration during development, modulate activity a various neurodegenerative diseases, pain more recently neuroendocrine functions. All these novel aspects, mainly focused on chemokine stromal cell-derived factor-1/CXCL12 its receptor CXCR4, were presented by pioneers field symposium held at sixth International Congress Neuroendocrinology Pittsburgh, Pennsylvania, USA June 2006.