MiR-21 in Substance P-induced exosomes promotes cell proliferation and migration in human colonic epithelial cells

作者: Kyriaki Bakirtzi , Ivy Ka Man Law , Kai Fang , Dimitrios Iliopoulos , Charalabos Pothoulakis

DOI: 10.1152/AJPGI.00043.2019

关键词: Cell biologyCell growthCell migrationMicrovesiclesChemistrySubstance PExosome production

摘要: Substance P signaling regulates exosome production in human colonic epithelial cells and crypts wild-type mice. MiR-21 is selectively sorted into exosomes induced by stimulat...

参考文章(58)
Leandro Venturutti, Lucía Virginia Romero, Alejandro Jorge Urtreger, María Florencia Chervo, Rosalia Ines Cordo Russo, María Florencia Mercogliano, Gloria Inurrigarro, MG Pereyra, CJ Proietti, Franco Izzo, Díaz Flaqué, Victoria Sundblad, Juan Carlos Roa, P Guzmán, ED Bal de Kier Joffe, Eduardo Hernan Charreau, Roxana Schillaci, Patricia Virginia Elizalde, Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis. Oncogene. ,vol. 35, pp. 2208- 2222 ,(2016) , 10.1038/ONC.2015.281
Kai Fang, Aristea Sideri, Ivy Ka Man Law, Kyriaki Bakirtzi, Christos Polytarchou, Dimitrios Iliopoulos, Charalabos Pothoulakis, Identification of a novel substance P (SP)-neurokinin-1 receptor (NK-1R) microRNA-221-5p inflammatory network in human colonic epithelial cells. Cellular and molecular gastroenterology and hepatology. ,vol. 1, pp. 503- 515 ,(2015) , 10.1016/J.JCMGH.2015.06.008
H.-W. Koon, D. Zhao, Y. Zhan, M. P. Moyer, C. Pothoulakis, Substance P mediates antiapoptotic responses in human colonocytes by Akt activation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 2013- 2018 ,(2007) , 10.1073/PNAS.0610664104
Dezheng Zhao, Sabina Kuhnt-Moore, Huiyan Zeng, Amy Pan, Jack S Wu, Simos Simeonidis, Mary P Moyer, Charalabos Pothoulakis, None, Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases. Biochemical Journal. ,vol. 368, pp. 665- 672 ,(2002) , 10.1042/BJ20020950
J. Mallegol, G. van Niel, M. Heyman, Phenotypic and functional characterization of intestinal epithelial exosomes. Blood Cells Molecules and Diseases. ,vol. 35, pp. 11- 16 ,(2005) , 10.1016/J.BCMD.2005.04.001
Hon Wai Koon, David Q. Shih, Tressia C. Hing, Jeremy Chen, Samantha Ho, Dezheng Zhao, Stephan R. Targan, Charalabos Pothoulakis, Substance P Induces CCN1 Expression via Histone Deacetylase Activity in Human Colonic Epithelial Cells The American Journal of Pathology. ,vol. 179, pp. 2315- 2326 ,(2011) , 10.1016/J.AJPATH.2011.07.038
Suresh Mathivanan, Hong Ji, Richard J. Simpson, Exosomes: extracellular organelles important in intercellular communication. Journal of Proteomics. ,vol. 73, pp. 1907- 1920 ,(2010) , 10.1016/J.JPROT.2010.06.006
Giovanna Leoni, Philipp-Alexander Neumann, Nazila Kamaly, Miguel Quiros, Hikaru Nishio, Hefin R. Jones, Ronen Sumagin, Roland S. Hilgarth, Ashfaqul Alam, Gabrielle Fredman, Ioannis Argyris, Emile Rijcken, Dennis Kusters, Chris Reutelingsperger, Mauro Perretti, Charles A. Parkos, Omid C. Farokhzad, Andrew S. Neish, Asma Nusrat, Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair Journal of Clinical Investigation. ,vol. 125, pp. 1215- 1227 ,(2015) , 10.1172/JCI76693
JUAN XIE, MING CHEN, JING ZHOU, MING-SHU MO, LI-HUI ZHU, YAN-PING LIU, QING-JUN GUI, LI ZHANG, GUO-QING LI, miR-7 inhibits the invasion and metastasis of gastric cancer cells by suppressing epidermal growth factor receptor expression. Oncology Reports. ,vol. 31, pp. 1715- 1722 ,(2014) , 10.3892/OR.2014.3052
Hon-Wai Koon, Dezheng Zhao, Xi Na, Mary P. Moyer, Charalabos Pothoulakis, Metalloproteinases and Transforming Growth Factor-α Mediate Substance P-induced Mitogen-activated Protein Kinase Activation and Proliferation in Human Colonocytes Journal of Biological Chemistry. ,vol. 279, pp. 45519- 45527 ,(2004) , 10.1074/JBC.M408523200