The ups and downs of miR-205: identifying the roles of miR-205 in mammary gland development and breast cancer.
作者： Stephanie B. Greene , Jason I. Herschkowitz , Jeffrey M. Rosen
关键词: Function (biology) 、 Cancer 、 Cancer research 、 Breast cancer 、 Stem cell 、 Biology 、 Suppressor 、 Metastasis 、 Oncogene 、 Immunology 、 Regulation of gene expression
摘要: Recent studies have demonstrated that miR-205 has a role in both normal development and cancer, however conflicting reports on its function illustrate the complexity of regulation targets. Additionally, was found to be highly expressed stem cell-enriched populations from mouse mammary gland, thus may play cell maintenance. The plays tumor formation metastasis is likely context-dependent as indicated it either suppressor or an oncogene. directing fate still unknown.
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