Circulating Cytokines and Granulocyte-Derived Enzymes During Complex Heart Surgery: A Clinical Study with Special Reference to Heparin-Coating of Cardiopulmonary Bypass Circuits

摘要: Blood contact with artificial surfaces during cardiopulmonary bypass (CPB) triggers a systemic inflammatory response in which complement, granulocytes and cytokines play major role. Heparin-coated CPB circuits were recently shown to reduce complement granulocyte activation such circumstances. The present study comprised 20 complex heart operations, 10 heparin-coated (group HC) controls C), evaluation of changes terminal complex, the enzymes myeloperoxidase lactoferrin, interleukin-6 (IL-6) interleukin-8 (IL-8). Standard heparin dose uncoated cardiotomy reservoir used all cases. In both groups levels rose significantly, beginning at conclusion CPB, above base values, without significant intergroup differences. IL-6 IL-8 also increased but tended be lower HC group, starting end continuing until hours postoperatively: for difference was (83 +/- 18 vs 197 39 micrograms/l, p = 0.21). Significantly thus found operations even use sets. heparin-coating seems diminish cytokine production.