Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth.
作者： Vicky Kottis , Pierre Thibault , Daniel Mikol , Zhi-Cheng Xiao , Rulin Zhang
DOI: 10.1046/J.1471-4159.2002.01146.X
关键词: Oligodendrocyte 、 Myelin 、 Oligodendrocyte-Myelin Glycoprotein 、 Neuroscience 、 Neuroglia 、 Neurite 、 Cell biology 、 Neuron 、 Biology 、 Dorsal root ganglion 、 Retinal ganglion
摘要: A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly oligodendrocyte-myelin glycoprotein (OMgp). We show that it is a potent inhibitor outgrowth rat cerebellar granule and hippocampal cells; dorsal root ganglion explants in which growth cone collapse was observed; retinal neurons; NG108 PC12 cells. OMgp by different procedure both mouse human myelin behaves identically all bioassays tested.
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