Karyometry of secretory cell nuclei in high-grade PIN lesions
作者： Peter H. Bartels , Rodolfo M. Montironi , David Bostwick , James Marshall , Deborah Thompson
DOI: 10.1002/PROS.1093
关键词: Basal cell layer 、 Prostate 、 Karyometry 、 Optical density 、 Anatomy 、 Secretory cell 、 High-Grade PIN 、 Pathology 、 Heterogeneous population 、 Biology 、 Intraepithelial neoplasia 、 Urology 、 Oncology
摘要: Background The goal of this study was a karyometric characterization secretory cell nuclei in high-grade prostatic intraepithelial neoplasia (PIN) lesions. Specifically, the hypothesis is tested that distinctly different subgroups exist these lesions. Methods High-resolution images 1,713 from PIN lesions were recorded. Karyometric features computed. Discriminant function scores against normal reference nuclei, and nuclear abnormality values derived. Data sets processed by nonsupervised learning algorithm to establish presence with statistically chromatin distributions. Results Three formed, facing an intact basal layer, near vanishing gap layer. For each set, formed three approximately equal sizes. Each subgroup found every one sampling locations. The total optical density distribution two suggests aneuploid distribution, third has diploid distribution. Conclusions Secretory are heterogeneous population, forming subgroups. Studies aimed at characterizing progression such should consider inhomogeneous nature nuclei. Prostate 48:144–155, 2001. © 2001 Wiley-Liss, Inc.
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