Intrahepatic response markers in chronic hepatitis B patients treated with peginterferon alpha-2a and adefovir
作者： Bart Takkenberg , Valeska Terpstra , Hans Zaaijer , Christine Weegink , Marcel Dijkgraaf
DOI: 10.1111/J.1440-1746.2011.06766.X
关键词: HBeAg 、 Hepatitis B virus 、 cccDNA 、 Gastroenterology 、 Antigen 、 Medicine 、 Pegylated interferon 、 HBcAg 、 Adefovir 、 Internal medicine 、 HBsAg 、 Hepatology
摘要: Background and Aim: We investigated whether intrahepatic markers could predict response in chronic hepatitis B virus (HBV) patients treated with peg-interferon adefovir for 48 weeks. Methods: Intrahepatic covalently closed circular DNA (cccDNA), total HBV the proportion of surface antigen (HBsAg) core (HBcAg) positive hepatocytes 16 e (HBeAg) 24 HBeAg negative were measured at baseline end treatment. Results: Baseline not associated sustained virological (SVR) defined as DNA < 2000 IU/mL persistent normal alanine aminotransferase levels follow-up (week 72). At treatment, cccDNA significantly lower seroconversion (P = 0.016 P = 0.010) predictive values (PPV) SVR 80% 80%, respectively. In patients, had declined treatment (P = 0.035 P = 0.041) corresponding PPV was 73% 82%. median HBcAg (P = 0.002) treatment. HBsAg (P = 0.0009). Using HBsAg ≤ 7.5% a limit, 83%. Conclusions: SVR. of < 7.5% strong predictor
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