Signal Transduction Mechanisms for Adenosine

摘要: Significant advances have been made during the last 20 yr in understanding mechanisms of adenosine receptor-mediated signal transduction at level plasma membrane. The pioneering studies early 1970s by Rall, Daly, Schwabe, and Fain clearly established that its analogs could modulate both cyclic AMP levels intact cells adenylate cyclase activity broken cell preparations. Systematic Londos Wolff (1977) estab­lished effects on be separated into those considered to (by so-called “R-site”), thus, amenable conceptual method­ological strategies available for study such processes, viewed as being mediated “P-sites,” which displayed few regulatory features exhibited previ­ously characterized extracellular receptors. Achieving this discrimi­nation set stage subsequent separation conventional (“R-site”) receptor two subtypes termed Ri Ra *, inhibited stimulated, with differing pharmacological profiles, respec­tively, membranes isolated from a wide variety (Londos et al., 1980). At nearly same time, Van Calker al. (1979) proposed subclassification “R-site” based production response range cultured lines.