Fibrinolysis in Cholestatic Jaundice

作者: A. Jedrychowski , P. Hillenbrand , A. B. Ajdukiewicz , S. P. Parbhoo , S. Sherlock

DOI: 10.1136/BMJ.1.5854.640

关键词: MedicineAntifibrinolytic agentGastroenterologyEndocrinologyInternal medicineCommon bile ductPrimary biliary cirrhosisUrokinaseFibrinolysisPalliative careCholestasisBile duct

摘要: The fibrinolytic system was studied in primary biliary cirrhosis (16 patients) and large bile duct obstruction (10 patients, nine of whom had carcinoma). Plasma fibrinolysis (plasminogen activator activity) decreased fibrinogen increased both groups particularly those with obstruction. These changes were related to the degree cholestasis. Plasminogen activity inversely serum triglyceride levels patients cirrhosis. Urokinase inhibitors antiplasmins obstruction; fibrin/fibrinogen degradation products normal moderately None these indices Fibrinolytic returned almost after palliative surgery three who studied. plasma may be due altered lipid metabolism cholestatic jaundice. In undergoing for there an risk thrombosis.

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