Method of improving signal-to-noise for quantitation by mass spectrometry

作者: Bruce A. Thomson , Blanc Yves Le

DOI:

关键词: Data acquisitionIonChemistryAnalytical chemistryTime-of-flight mass spectrometryIntensity (physics)Window (computing)Mass spectrometryMass spectrumIon current

摘要: Selectivity of a measurement from mass spectrometer is improved by selecting an extracted ion current window for the after data acquisition. A plurality spectra are acquired over period time. first selected and intensity as function time calculated using window. second signal-to-noise ratio compared with intensity. If greater than ratio, used measurement.

参考文章(23)
Kenneth R. Weiner, Philip L. Wylie, James H. Crabtree, Retention time-locked spectral database for target analyte analysis ,(1998)
Thomas George, Clare Livingston Bromley, Sandeep Gulati, James Kelly Breaux, Shahar Ben-Menahem, Analyzing Information Gathered Using Multiple Analytical Techniques ,(2007)
Atsumu Hirabayashi, Kiyomi Yoshinari, Toshiyuki Yokosuka, Akihiro Sano, Yasushi Terui, Kinya Kobayashi, Kenko Uchida, Mass spectrometer system ,(2004)
Armin Graber, Peter Juhasz, Dale H. Patterson, Stephen A. Martin, Method for characterizing biomolecules utilizing a result driven strategy ,(2003)
Kristin H. Jarman, Don Simone Daly, Kevin K. Anderson, Karen L. Wahl, Identification of features in indexed data and equipment therefore ,(2001)
Michael Bernstein, Jerry K. Okikawa, Terrence R. Bennett, Charles A. Richardson, Method and apparatus for reducing ambient noise effects in electronic monitoring instruments. ,(1993)
Ziping Yang, Marina Hincapie, William S. Hancock, Multi-lectin affinity chromatography and uses thereof ,(2005)
Sílvia Lacorte, Amadeo R. Fernandez‐Alba, Time of flight mass spectrometry applied to the liquid chromatographic analysis of pesticides in water and food. Mass Spectrometry Reviews. ,vol. 25, pp. 866- 880 ,(2006) , 10.1002/MAS.20094
María José Gómez, Octavio Malato, Imma Ferrer, Ana Agüera, Amadeo R. Fernández-Alba, Solid-phase extraction followed by liquid chromatography–time-of-flight–mass spectrometry to evaluate pharmaceuticals in effluents. A pilot monitoring study Journal of Environmental Monitoring. ,vol. 9, pp. 718- 729 ,(2007) , 10.1039/B702844J