Methods of regulating angiogenesis by administering agents which increase apoB-100 polypeptide

作者: Inbal Avraham-Davidi , Karina Yaniv , Yogev Sela

DOI:

关键词: Internal medicineAngiogenesisEndocrinologyMedicineApolipoprotein BPharmacology

摘要: A method of treating an angiogenesis related disease or disorder in a subject need thereof is disclosed. The comprises administering to the therapeutically effective amount agent which regulates apolipoprotein B (ApoB), and/or ability ApoB transcriptionally control vascular endothelial growth factor receptor 1 (VEGFR1).

参考文章(14)
Akin Akinc, James Butler, Tomoko Nakayama, Compositions and methods for delivering rnai using apoe ,(2010)
George Baillie, Moira Doreen Owens, Gavin William Halbert, Non-naturally occurring lipoprotein particle ,(1997)
Inbal Avraham-Davidi, Karina Yaniv, Yogev Sela, Methods of regulating angiogenesis and compositions capable of same ,(2012)
Stephen Scaringe, Devin Leake, Steven Read, William Marshall, Anastasia Khvorova, Angela Reynolds, SiRNA targeting apolipoprotein B (APOB) ,(2010)
Lloyd B. Jeffs, Lorne R. Palmer, Amy C. H. Lee, Adam Judge, Vandana Sood, Ian Maclachlan, siRNA silencing of apolipoprotein B ,(2005)
Linda Salomonsson, Linda Svensson, Sofia Pettersson, Olov Wiklund, Bertil G Ohlsson, None, Oxidised LDL decreases VEGFR-1 expression in human monocyte-derived macrophages Atherosclerosis. ,vol. 169, pp. 259- 267 ,(2003) , 10.1016/S0021-9150(03)00202-8
Inbal Avraham-Davidi, Yona Ely, Van N Pham, Daniel Castranova, Moshe Grunspan, Guy Malkinson, Liron Gibbs-Bar, Oded Mayseless, Gabriella Allmog, Brigid Lo, Carmen M Warren, Tom T Chen, Josette Ungos, Kameha Kidd, Kenna Shaw, Ilana Rogachev, Wuzhou Wan, Philip M Murphy, Steven A Farber, Liran Carmel, Gregory S Shelness, M Luisa Iruela-Arispe, Brant M Weinstein, Karina Yaniv, ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1 Nature Medicine. ,vol. 18, pp. 967- 973 ,(2012) , 10.1038/NM.2759
Zoltán Süle, Éva Mracskó, Erika Bereczki, Miklós Sántha, Tamás Csont, Péter Ferdinandy, Ferenc Bari, Eszter Farkas, Capillary injury in the ischemic brain of hyperlipidemic, apolipoprotein B-100 transgenic mice Life Sciences. ,vol. 84, pp. 935- 939 ,(2009) , 10.1016/J.LFS.2009.04.011