Primary Alcohols from Terminal Olefins: Formal Anti-Markovnikov Hydration via Triple Relay Catalysis

摘要: Alcohol synthesis is critical to the chemical and pharmaceutical industries. The addition of water across olefins form primary alcohols (anti-Markovnikov olefin hydration) would be a broadly useful reaction but has largely proven elusive; an indirect hydroboration/oxidation sequence requiring stoichiometric borane oxidant currently most practical methodology. Here, we report more direct approach with use triple relay catalysis system that couples palladium-catalyzed oxidation, acid-catalyzed hydrolysis, ruthenium-catalyzed reduction cycles. Aryl-substituted terminal are converted by net in good yield excellent regioselectivity.