I.C.I. 35868 - The effect of a change of formulation on the incidence of pain after intravenous injection.

摘要: I.C.I. 35868 is a promising new intravenous induction agent, but injection of the initial 2% formulation frequently caused pain. The solvent vehicle formulation, which contained Cremophor E.L. and ethanol, was therefore investigated to see if this could be cause Twenty volunteers received both 5 ml isotonic saline intravenously. never pain, mild or moderate pain in 9 patients. reformulated 1% solution, excluding ethanol from solvent. When compared methohexitone 24 patients, agents Four out 12 patients reveiving felt with total "score" 6, 6 who 1%, 12. In no instance followed by persistant evidence thrombosis phlebitis.