Headache in systemic lupus erythematosus: results from a prospective, international inception cohort study.

摘要: ObjectiveTo examine the frequency and characteristics of headaches their association with global disease activity health-related quality life (HRQOL) in patients systemic lupus erythematosus (SLE). MethodsA inception cohort was assessed annually for headache (5 types) 18 other neuropsychiatric (NP) events. Global scores (SLE Disease Activity Index 2000 [SLEDAI-2K]), damage (Systemic Lupus International Collaborating Clinics/American College Rheumatology Damage [SDI]), Short Form 36 (SF-36) mental physical component summary were collected. Time to first associations SF-36 analyzed using Cox proportional hazards linear regression models generalized estimating equations. ResultsAmong 1,732 SLE enrolled, 89.3% female 48.3% white. The mean SD age 34.6 +/- 13.4 years, duration 5.6 5.2 months, length followup 3.8 3.1 years. At enrollment, 17.8% had (migraine [60.7%], tension [38.6%], intractable nonspecific [7.1%], cluster [2.6%], intracranial hypertension [1.0%]). prevalence increased 58% after 10 Only 1.5% headache, as identified SLEDAI-2K. In addition, associated NP events attributed either or non-SLE causes. There no SLEDAI-2K (without variable), SDI scores, use corticosteroids, antimalarials, immunosuppressive medications, specific autoantibodies. lower compared those without (mean 42.5 12.2 versus 47.8 11.3; P < 0.001), similar differences seen (38.0 11.0 42.6 11.4 headache; 0.001). 56.1% patients, resolved over followup. ConclusionHeadache is frequent SLE, but overall, it not Although are a HRQOL, majority resolve time, independent lupus-specific therapies. (Less)