Tongluo Xingnao effervescent tablet reverses memory deficit and reduces plaque load in APPswe/PS1dE9 mice

摘要: Alzheimer's disease (AD) is the most common type of dementia. Amyloid-β (Aβ)-induced neurodegeneration hypothesized to be primary pathological mechanism AD. Tongluo Xingnao effervescent tablets (TXET), based on traditional Chinese formula Qionggui Tang, have been used treat AD and other types dementia in China for decades. In present study, effects TXET cognition deficit, amyloid-β production, amyloid precursor protein procession β-secretase expression were investigated APPswe/PS1dE9 mouse model As expected, mice exhibited cognitive decline higher levels Aβ plaques brain compared with normal mice; however, these changes attenuated following treatment. Levels C-terminal fragment (CTF)-β decreased treatment TXET; CTF-α unaffected. Furthermore, did not decrease γ-secretase activity or presenilin-1 (PS1), neprilysin insulin-degrading enzyme. These results indicate that may regulate metabolism by downregulating β-secretase. The study laid foundation development a medicinal compound inhibitor as target