Antiaging effects of bioactive molecules isolated from plants and fungi

作者: Jan Martel , David M. Ojcius , Yun-Fei Ko , Chih-Jung Chang , John D. Young

DOI: 10.1002/MED.21559

关键词: AutophagyInsulinCell biologyNeurodegenerationReactive oxygen speciesDNA repairDiseaseModel organismBiologyCalorie restriction

摘要: … /GH/IGF-1 axis.42 Also … hematopoiesis and hematopoietic stem cell self-renewal in old mice,317 indicating that compounds that inhibit mTOR may delay aging by improving stem cell …

参考文章(340)
Abhirup Das, George X Huang, Michael S Bonkowski, Alban Longchamp, Catherine Li, Michael B Schultz, Lynn-Jee Kim, Brenna Osborne, Sanket Joshi, Yuancheng Lu, Jose Humberto Treviño-Villarreal, Myung-Jin Kang, Tzong-tyng Hung, Brendan Lee, Eric O Williams, Masaki Igarashi, James R Mitchell, Lindsay E Wu, Nigel Turner, Zolt Arany, Leonard Guarente, David A Sinclair, None, Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging Cell. ,vol. 173, pp. 74- 89.e20 ,(2018) , 10.1016/J.CELL.2018.02.008
Han Dai, David A. Sinclair, James L. Ellis, Clemens Steegborn, Sirtuin activators and inhibitors : Promises, achievements, and challenges Pharmacology & Therapeutics. ,vol. 188, pp. 140- 154 ,(2018) , 10.1016/J.PHARMTHERA.2018.03.004
Yujun Hou, Sofie Lautrup, Stephanie Cordonnier, Yue Wang, Deborah L. Croteau, Eduardo Zavala, Yongqing Zhang, Kanako Moritoh, Jennifer F. O’Connell, Beverly A. Baptiste, Tinna V. Stevnsner, Mark P. Mattson, Vilhelm A. Bohr, NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 115, pp. 201718819- ,(2018) , 10.1073/PNAS.1718819115
Christopher R. Martens, Blair A. Denman, Melissa R. Mazzo, Michael L. Armstrong, Nichole Reisdorph, Matthew B. McQueen, Michel Chonchol, Douglas R. Seals, Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults Nature Communications. ,vol. 9, pp. 1286- 1286 ,(2018) , 10.1038/S41467-018-03421-7
Kai Mao, Gabriela Farias Quipildor, Tahmineh Tabrizian, Ardijana Novaj, Fangxia Guan, Ryan O. Walters, Fabien Delahaye, Gene B. Hubbard, Yuji Ikeno, Keisuke Ejima, Peng Li, David B. Allison, Hossein Salimi-Moosavi, Pedro J. Beltran, Pinchas Cohen, Nir Barzilai, Derek M. Huffman, Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nature Communications. ,vol. 9, pp. 2394- 2394 ,(2018) , 10.1038/S41467-018-04805-5
Federico Pietrocola, Francesca Castoldi, Maria Chiara Maiuri, Guido Kroemer, Aspirin—another caloric-restriction mimetic Autophagy. ,vol. 14, pp. 1162- 1163 ,(2018) , 10.1080/15548627.2018.1454810
Stefan Kiechl, Raimund Pechlaner, Peter Willeit, Marlene Notdurfter, Bernhard Paulweber, Karin Willeit, Philipp Werner, Christoph Ruckenstuhl, Bernhard Iglseder, Siegfried Weger, Barbara Mairhofer, Markus Gartner, Ludmilla Kedenko, Monika Chmelikova, Slaven Stekovic, Hermann Stuppner, Friedrich Oberhollenzer, Guido Kroemer, Manuel Mayr, Tobias Eisenberg, Herbert Tilg, Frank Madeo, Johann Willeit, Higher spermidine intake is linked to lower mortality: a prospective population-based study. The American Journal of Clinical Nutrition. ,vol. 108, pp. 371- 380 ,(2018) , 10.1093/AJCN/NQY102
Ming Xu, Tamar Pirtskhalava, Joshua N. Farr, Bettina M. Weigand, Allyson K. Palmer, Megan M. Weivoda, Christina L. Inman, Mikolaj B. Ogrodnik, Christine M. Hachfeld, Daniel G. Fraser, Jennifer L. Onken, Kurt O. Johnson, Grace C. Verzosa, Larissa G. P. Langhi, Moritz Weigl, Nino Giorgadze, Nathan K. LeBrasseur, Jordan D. Miller, Diana Jurk, Ravinder J. Singh, David B. Allison, Keisuke Ejima, Gene B. Hubbard, Yuji Ikeno, Hajrunisa Cubro, Vesna D. Garovic, Xiaonan Hou, S. John Weroha, Paul D. Robbins, Laura J. Niedernhofer, Sundeep Khosla, Tamara Tchkonia, James L. Kirkland, Senolytics improve physical function and increase lifespan in old age Nature Medicine. ,vol. 24, pp. 1246- 1256 ,(2018) , 10.1038/S41591-018-0092-9
Tsung-Ru Wu, Chuan-Sheng Lin, Chih-Jung Chang, Tzu-Lung Lin, Jan Martel, Yun-Fei Ko, David M Ojcius, Chia-Chen Lu, John D Young, Hsin-Chih Lai, Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis. Gut. ,vol. 68, pp. 248- 262 ,(2019) , 10.1136/GUTJNL-2017-315458
John J McNeil, Robyn L Woods, Mark R Nelson, Christopher M Reid, Brenda Kirpach, Rory Wolfe, Elsdon Storey, Raj C Shah, Jessica E Lockery, Andrew M Tonkin, Anne B Newman, Jeff D Williamson, Karen L Margolis, Michael E Ernst, Walter P Abhayaratna, Nigel Stocks, Sharyn M Fitzgerald, Suzanne G Orchard, Ruth E Trevaks, Lawrence J Beilin, Geoffrey A Donnan, Peter Gibbs, Colin I Johnston, Joanne Ryan, Barbara Radziszewska, Richard Grimm, Anne M Murray, None, Effect of Aspirin on Disability-free Survival in the Healthy Elderly The New England Journal of Medicine. ,vol. 379, pp. 1499- 1508 ,(2018) , 10.1056/NEJMOA1800722