The Rho-A/Rho-kinase pathway is up-regulated but remains inhibited by cyclic guanosine monophosphate-dependent mechanisms during endotoxemia in small mesenteric arteries.

作者： J Eduardo da Silva-Santos , Chin-Wei Chiao , Romulo Leite , R Clinton Webb

关键词: Vasoconstriction 、 Vasodilation 、 Intensive care 、 Cyclic guanosine monophosphate 、 Endocrinology 、 Internal medicine 、 Ex vivo 、 Signal transduction 、 Rho-associated protein kinase 、 Mesenteric arteries 、 Biology

摘要: Objective:We investigated whether a reduced activity in the Rho-A/Rho-kinase pathway could be involved impaired vascular reactivity observed septic shock.Design:Ex vivo animal study.Setting:University research laboratory.Subjects:Male Wistar rats.Interventions:Rats received an intraperiton

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The Rho-A/Rho-kinase pathway is up-regulated but remains inhibited by cyclic guanosine monophosphate-dependent mechanisms during endotoxemia in small mesenteric arteries.

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The Rho-A/Rho-kinase pathway is up-regulated but remains inhibited by cyclic guanosine monophosphate-dependent mechanisms during endotoxemia in small mesenteric arteries.

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