Shape memory polyurethanes with oxidation-induced degradation: In vivo and in vitro correlations for endovascular material applications.

摘要: The synthesis of thermoset shape memory polymer (SMP) polyurethanes from symmetric, aliphatic alcohols and diisocyanates has previously demonstrated excellent biocompatibility in short term vitro vivo studies, although long stability not been investigated. Here we demonstrate that while rapid oxidation occurs these SMPs, facilitated by the incorporation multi-functional, branching amino groups, byproduct analysis does indicate toxicological concern for materials. Through complex multi-step chemical reactions, chain scission begins amines monomeric repeat units, results, ultimately, formation carboxylic acids, secondary primary amines; degradation rate product concentrations were confirmed using liquid chromatography mass spectrometry, model compound yielding a unexamined mechanism biomaterials. is dependent on hydrogen peroxide concentration, comparison explanted samples reveals much slower compared to widely accepted literature real-time equivalent 3% H2O2. Cytotoxicity studies material surface, examination accumulations, negligible impact cytotoxicity