Interleukin-8. A corneal factor that induces neovascularization.

摘要: A rabbit corneal pocket model was used to demonstrate that physiologic concentrations of human recombinant (r) IL-8 may induce neovascularization. Computer-assisted analysis sequential fluorescein angiograms showed rIL-8 doses ranging from 2 40 ng/cornea (P = 0.01), but not high dose (400 ng/cornea), results in neovascularization within 14 days. Repeat 6 weeks after placing angiogenic demonstrated significant regression 0.01) the vascularity present at weeks, suggesting angiogenesis undergoes dynamic modulation similar normally seen wound healing. To our knowledge, this is first study showing an role for IL-8, a finding emphasizes interplay between inflammation and Our imply corneal-derived be important neovascularization, particular, modulate healing general. Finally, these raise possibility cytokines, such as obfuscate effects agents tested experimental models.