Filopodia as detectors of environmental cues: signal integration through changes in growth cone calcium levels.

摘要: Publisher Summary This chapter examines a selected series of environmental stimuli that are known to interact with growth cones and how these translated by the second messenger systems intrinsic cone proper. In particular, this emphasizes role intracellular calcium ions as translating extracellular cues into changes in neuronal behavior. The effects two distinctive classes external examined: neurotransmitters membrane protein NI-35, derived from central nervous system oligodendrocytes. discussion also describes sets within cell. text provides description what is now termed hypothesis for control Finally, an extended set roles individual components interact. doing so, presents antennae amplifier model filopodia/growth interaction incorporates distant filopodia graded actions