Profiling leucocyte subsets in tuberculosis–diabetes co-morbidity
作者： Nathella Pavan Kumar , Kadar Moideen , Sharmila D Dhakshinraj , Vaithilingam V Banurekha , Dina Nair
DOI: 10.1111/IMM.12496
关键词: CD8 、 Immunology 、 Biology 、 Pathogenesis 、 Myeloid 、 Latent tuberculosis 、 Homeostasis 、 Immune system 、 Tuberculosis 、 Diabetes mellitus
摘要: The immune system plays an important role in the pathogenesis of pulmonary tuberculosis-type 2 diabetes mellitus (PTB-DM) co-morbidity. However, phenotypic profile leucocyte subsets at homeostasis individuals with active or latent tuberculosis (LTB) coincident is not known. To characterize influence on phenotypes PTB LTB, we examined frequency (Fo ) TB without (PTB) diabetes; (LTB-DM) and non-TB-infected (NTB-DM) (NTB) diabetes. Coincident DM characterized by significantly lower Fo effector memory CD4(+) T cells LTB individuals. In contrast, CD8(+) higher central resulted classical B activated atypical intermediate monocytes PTB, NTB Finally, myeloid plasmacytoid dendritic Our data reveal that alters cellular subset distribution cells, both those TB, thus potentially impacting this co-morbid condition.
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