Blood homocysteine concentration and mood disorders with mixed features among patients with alcohol use disorder

摘要: Blood homocysteine concentration (BHC) is higher in patients with alcohol use disorder (AUD). Previous studies have found a relationship between depressive symptoms severity and BHC AUD recently some authors high among bipolar disorder, both during manic episodes euthymic state. However, mixed mood episode has not yet been investigated. The aim of this study was to evaluate the episode. A sample outpatients assessed by Mini-International Neuropsychiatric Interview (MINI Plus): those DSM-IV-TR features were included MIXED group (n = 45), whereas without gathered NO MOOD (n = 23). Two subgroups, MIXMANIA MIXDEPRESSION, formed according prevalence or symptoms, Young Mania Rating Scale (YMRS), Hamilton for Depression (HDRS). Alcohol Use Disorder Identification Test (AUDIT) used appraise AUD. determined High-Performance Liquid Chromatography. showed greater (26.35 ± 9.96 vs. 4.77 ± 0.92; p < 0.001) (22.35 ± 3.30 6.14 ± 1.12; (28.80 ± 11.47 10.83 ± 2.81; p < 0.001), than group. strongly correlated HDRS, YMRS AUDIT scores, just as HDRS YMRS, only (p < 0.001). MIXDEPRESSION subgroup (Mdn = 42.96, IQR = 10.44 Mdn = 19.77, IQR = 5.93; p < 0.001). linear regression model conducted on significant predictive value (β = 0.560, t = 2.43, p = 0.026) (β = 0.348, t = 2.17, p = 0.044). Depressive seem be mainly implicated elevation