Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability.
作者： Ester Carballo , Wi S. Lai , Perry J. Blackshear
关键词: Messenger RNA 、 Zinc finger 、 Tumor necrosis factor alpha 、 Granulocyte macrophage colony-stimulating factor 、 ZFP36 、 Receptor 、 Biochemistry 、 Biology 、 Tristetraprolin 、 Cell biology 、 Regulator
摘要: Deficiency of tristetraprolin (TTP), the prototype CCCH zinc finger proteins, results in a complex inflammatory syndrome mice. Most aspects are secondary to excess circulating tumor necrosis factor (TNF)–, consequence increased stability TNF- messenger RNA (mRNA) TTP-deficient macrophages. TTP can bind directly AU-rich element mRNA, increasing its lability. Here we show that deficiency also cellular production granulocyte-macrophage colony–stimulating (GM-CSF) and apparently decreased deadenylation. Similar findings were observed mice lacking both types receptors, excluding as cause GM-CSF mRNA levels stability. appears be physiological regulator deadenylation
ashpublications.org
bloodjournal.org参考文章(51)
HJ Ross, N Sato, Y Ueyama, HP Koeffler, Cytokine messenger RNA stability is enhanced in tumor cells Blood. ,vol. 77, pp. 1787- 1795 ,(1991) , 10.1182/BLOOD.V77.8.1787.1787
E. Stanley, D. Metcalf, P. Sobieszczuk, N.M. Gough, A.R. Dunn, The structure and expression of the murine gene encoding granulocyte-macrophage colony stimulating factor: evidence for utilisation of alternative promoters. The EMBO Journal. ,vol. 4, pp. 2569- 2573 ,(1985) , 10.1002/J.1460-2075.1985.TB03972.X
H. Leppens, G. Schoeters, R. Van Den Heuvel, O. Vanderdfborght, Stromal cells in long-term cultures of liver, spleen, and bone marrow at different developmental ages have different capacities to maintain GM-CFC proliferation. Experimental Hematology. ,vol. 19, pp. 115- 121 ,(1991)
Daniel Nathans, Michael W. McLane, Lester F. Lau, Kevin Ryder, Raymond N. DuBois, A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. Journal of Biological Chemistry. ,vol. 265, pp. 19185- 19191 ,(1990) , 10.1016/S0021-9258(17)30642-7
W S Lai, D J Stumpo, P J Blackshear, Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein. Journal of Biological Chemistry. ,vol. 265, pp. 16556- 16563 ,(1990) , 10.1016/S0021-9258(17)46259-4
C.A. Beelman, R. Parker, Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA. Journal of Biological Chemistry. ,vol. 269, pp. 9687- 9692 ,(1994) , 10.1016/S0021-9258(17)36937-5
C Y Chen, N Xu, A B Shyu, mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation. Molecular and Cellular Biology. ,vol. 15, pp. 5777- 5788 ,(1995) , 10.1128/MCB.15.10.5777
C Y Chen, A B Shyu, Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements. Molecular and Cellular Biology. ,vol. 14, pp. 8471- 8482 ,(1994) , 10.1128/MCB.14.12.8471
H P Koeffler, J Gasson, A Tobler, Transcriptional and posttranscriptional modulation of myeloid colony-stimulating factor expression by tumor necrosis factor and other agents. Molecular and Cellular Biology. ,vol. 8, pp. 3432- 3438 ,(1988) , 10.1128/MCB.8.8.3432
Francesca Chiaffarino, Carla Zoja, Alessandro Rambaldi, Stefania Bettoni, Jo Van Damme, Alberto Mantovani, Giuseppe Remuzzi, Daniela Renzi, Marina Sironi, Hanna E. Abboud, Ji Ming Wang, Interleukin-1β and tumor necrosis factor-α induce gene expression and production of leukocyte chemotactic factors, colony-stimulating factors, and interleukin-6 in human mesangial cells American Journal of Pathology. ,vol. 138, pp. 991- 1003 ,(1991)