Impact of Androgens on Inflammation-Related Lipid Mediator Biosynthesis in Innate Immune Cells.

摘要: Rheumatoid arthritis, asthma, allergic rhinitis and many other disorders related to an aberrant immune response have a higher incidence severity in women than men. Emerging evidences from scientific studies indicate that the activity of system is superior females androgens may act as "immunosuppressive" molecules with inhibitory effects on inflammatory reactions. Among multiple factors contribute response, lipid mediators (LM), produced polyunsaturated fatty acids, represent class bioactive small pivotal roles onset, maintenance resolution inflammation. LM encompass pro-inflammatory eicosanoids specialized pro-resolving (SPM) coexist tightly regulated balance necessary for return homeostasis. Innate cells including neutrophils, monocytes macrophages possess high capacities generate distinct LM. In last decades it became more evident sex represents important variable regulation inflammation where hormones play crucial roles. Recent findings showed biosynthesis inflammation-related sex-biased impact formation consequences not only pathophysiology but also pharmacotherapy. Here, we review modulation by specific focus pathways. particular, highlight biosynthetic pathway innate cells.