Evidence for a receptor-mediated mechanism for sorting proopiomelanocortin to the regulated secretory pathway
作者： Y. P. Loh , C. R. Snell , D. R. Cool
DOI: 10.1007/978-3-0348-9010-6_6
关键词: Proopiomelanocortin 、 Receptor 、 Internal medicine 、 Neuroendocrine cell 、 Prohormone 、 Amino acid 、 Chemistry 、 Endocrinology 、 Cell biology 、 Golgi apparatus 、 Receptor-mediated endocytosis 、 Secretory pathway
摘要: A sorting signal which directs the prohormone pro-opiomelanocortin (POMC) to regulated secretory pathway was identified. This motif consists of a 13 amino acid (POMC8–20) amphipathic loop stabilized by disulfide bridge (Cys8–Cys20) located at N-terminus pro-opiomelanocortin. It binds an acidic pH specifically ~64 kD receptor protein present in Golgi and granule membranes neuroendocrine cells. These findings support hypothesis that is targeted receptor-mediated mechanism.
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