Glucocorticoids induce gastroparesis in mice through depletion of l-arginine.

摘要: Glucocorticoids (GCs) constitute a highly pleiotropic class of drugs predominantly employed in the treatment inflammatory diseases. In our search for new mechanisms action, we identified hitherto unknown effect GCs gastrointestinal tract. We found that oral administration dexamethasone (Dex) to mice caused an enlargement stomach due induction gastroparesis and this was abolished GRdim carrying A458T mutation GC receptor (GR). Gastroparesis unrelated enhanced gastric acid secretion observed after Dex treatment, although both effects were mediated by same molecular mechanism GR. Using conditional GR-knockout mice, could further rule out on enterocytes or myeloid cells involved gastroparesis. contrast, upregulated arginase 2 (Arg2) at mRNA protein level. This suggests leads depletion l-arginine thereby...