Distribution of antenatal alloimmunization in the southern districts of West Bengal and its significant associated factor.

摘要: Objectives: Detection of maternal irregular antibodies against red blood cell antigen is vital in the management hemolytic disease fetus and newborn. There are no uniform guidelines related to antenatal antibody screening identification developing Country like India. This study was aimed identify such alloimmunization its associations. Materials Methods: prospective conducted on mothers at a tertiary care center. The having history anti-D administration, transfusion, autoimmune disorders were excluded from study. Initial indirect antiglobulin test (IAT) performed all samples by conventional tube technique (CTT) alloimmunization. IAT-positive screened for column agglutination technology (CAT). Antibody screen-positive further analyzed 11-cell panel CAT. strength measured serial double dilution CTT. source isoimmunization identified extended Rh phenotype women, husband, Results: A total 12 (2.3%) women out 530 positive IAT screen. could be 11 which (5) most common, followed anti-C + (4), anti-E (1), (1). All four cases distinguished anti-G differential adsorption elution. significant association with versus increased gravid status, antepartum hemorrhage, past newborns neonatal jaundice. Conclusion: pregnant haemorrhage, newborn jundice should alloantibody early detection better HDFN.