Studying epigenetic complexes and their inhibitors with the proteomics toolbox.

Paul Bamborough, Chun-wa Chung, Rebecca C. Furze, Paola Grandi, Anne-Marie Michon, Robert J. Sheppard, Heather Barnett, Hawa Diallo, David P. Dixon, Clement Douault, Emma J. Jones, Bhumika Karamshi, Darren J. Mitchell, Rab K. Prinjha, Christina Rau, Robert J. Watson, Thilo Werner, Emmanuel H. Demont, Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors. Journal of Medicinal Chemistry. ,vol. 58, pp. 6151- 6178 ,(2015) , 10.1021/ACS.JMEDCHEM.5B00773

Hans V. Westerhoff, Shintaro Nakayama, Thierry D.G.A. Mondeel, Matteo Barberis, Systems Pharmacology: An opinion on how to turn the impossible into grand challenges. Drug Discovery Today: Technologies. ,vol. 15, pp. 23- 31 ,(2015) , 10.1016/J.DDTEC.2015.06.006

Tewis Bouwmeester, Angela Bauch, Heinz Ruffner, Pierre-Olivier Angrand, Giovanna Bergamini, Karen Croughton, Cristina Cruciat, Dirk Eberhard, Julien Gagneur, Sonja Ghidelli, Carsten Hopf, Bettina Huhse, Raffaella Mangano, Anne-Marie Michon, Markus Schirle, Judith Schlegl, Markus Schwab, Martin A. Stein, Andreas Bauer, Georg Casari, Gerard Drewes, Anne-Claude Gavin, David B. Jackson, Gerard Joberty, Gitte Neubauer, Jens Rick, Bernhard Kuster, Giulio Superti-Furga, A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nature Cell Biology. ,vol. 6, pp. 97- 105 ,(2004) , 10.1038/NCB1086

Cheryl H Arrowsmith, James E Audia, Christopher Austin, Jonathan Baell, Jonathan Bennett, Julian Blagg, Chas Bountra, Paul E Brennan, Peter J Brown, Mark E Bunnage, Carolyn Buser-Doepner, Robert M Campbell, Adrian J Carter, Philip Cohen, Robert A Copeland, Ben Cravatt, Jayme L Dahlin, Dashyant Dhanak, Aled M Edwards, Mathias Frederiksen, Stephen V Frye, Nathanael Gray, Charles E Grimshaw, David Hepworth, Trevor Howe, Kilian V M Huber, Jian Jin, Stefan Knapp, Joanne D Kotz, Ryan G Kruger, Derek Lowe, Mary M Mader, Brian Marsden, Anke Mueller-Fahrnow, Susanne Müller, Ronan C O'Hagan, John P Overington, Dafydd R Owen, Saul H Rosenberg, Ruth Ross, Bryan Roth, Matthieu Schapira, Stuart L Schreiber, Brian Shoichet, Michael Sundström, Giulio Superti-Furga, Jack Taunton, Leticia Toledo-Sherman, Chris Walpole, Michael A Walters, Timothy M Willson, Paul Workman, Robert N Young, William J Zuercher, The promise and peril of chemical probes. Nature Chemical Biology. ,vol. 11, pp. 536- 541 ,(2015) , 10.1038/NCHEMBIO.1867

Zhen-Ning Zhang, Sun-Ku Chung, Zheng Xu, Yang Xu, Oct4 Maintains the Pluripotency of Human Embryonic Stem Cells by Inactivating p53 Through Sirt1-Mediated Deacetylation STEM CELLS. ,vol. 32, pp. 157- 165 ,(2014) , 10.1002/STEM.1532

A. C. Crecelius, U. S. Schubert, F. von Eggeling, MALDI mass spectrometric imaging meets "omics": recent advances in the fruitful marriage. Analyst. ,vol. 140, pp. 5806- 5820 ,(2015) , 10.1039/C5AN00990A

Michael Höfener, Fiona Pachl, Bernhard Kuster, Norbert Sewald, Inhibitor-based affinity probes for the investigation of JAK signaling pathways PROTEOMICS. ,vol. 15, pp. 3066- 3074 ,(2015) , 10.1002/PMIC.201400324

Verena K. Maier, Caitlin M. Feeney, Jordan E. Taylor, Amanda L. Creech, Jana W. Qiao, Attila Szanto, Partha P. Das, Nicholas Chevrier, Catherine Cifuentes-Rojas, Stuart H. Orkin, Steven A. Carr, Jacob D. Jaffe, Philipp Mertins, Jeannie T. Lee, Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator Molecular & Cellular Proteomics. ,vol. 14, pp. 1435- 1446 ,(2015) , 10.1074/MCP.M114.044586

Sue E. Hutchinson, Melanie V. Leveridge, Michelle L. Heathcote, Peter Francis, Laura Williams, Michelle Gee, Jordi Munoz-Muriedas, Bill Leavens, Anthony Shillings, Emma Jones, Paul Homes, Stuart Baddeley, Chun-wa Chung, Angela Bridges, Argyrides Argyrou, Enabling Lead Discovery for Histone Lysine Demethylases by High-Throughput RapidFire Mass Spectrometry Journal of Biomolecular Screening. ,vol. 17, pp. 39- 48 ,(2012) , 10.1177/1087057111416660

J. Taunton, C. A. Hassig, S. L. Schreiber, A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p Science. ,vol. 272, pp. 408- 411 ,(1996) , 10.1126/SCIENCE.272.5260.408