Diagnostic techniques for inflammatory eye disease: past, present and future: a review

作者: Stephen C Teoh , Andrew D Dick

DOI: 10.1186/1471-2415-13-41

关键词: Intensive care medicineMedicinePatient stratificationDiseaseReview articleMedical diagnosisTreatment optionsImmunologyPosner-Schlossman syndromeACUTE ANTERIOR UVEITISClinical trial

摘要: Investigations used to aid diagnosis and prognosticate outcomes in ocular inflammatory disorders are based on techniques that have evolved over the last two centuries dramatically with advances molecular biological imaging technology. Our improved understanding of basic processes infective drives innate immunity bridging engagement adaptive formed tailor develop assays, deliver targeted treatment options. Diagnostic paramount distinguish from non-infective intraocular disease, particularly atypical cases. The enabled our ability multiplex assay small amount specimen quantities samples including aqueous, vitreous or tissue samples. Nevertheless achieve diagnosis, often require a range assays traditional hypersensitivity reactions microbe specific immunoglobulin analysis modern cytokine analysis. Such approaches capitalise advantages each technique, thereby improving sensitivity specificity diagnoses. This review article highlights development laboratory diagnostic for now readily available assist accurate identification agents appropriation appropriate therapies as well formulating patient stratification alongside clinical diagnoses into disease groups trials.

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