Is reduction of viral fitness a valid antiviral approach

摘要: Viral fitness, the replicative adaptation of a virus to its environment, has viral and environmental determinants. Presently, growth competition assays recombinant viruses can supply precise evaluation this parameter potential clinical interest. On basis data obtained by monitoring infections under treatment with antiviral compounds sequence-function analysis drug-resistant variants, it recently been proposed that intentional selection mutants reduced fitness could be an efficient strategy in several important humans. From point view, specific as well human monoclonal antibodies targeting crucial proteins effective modifying replication capacity pathogenic rapidly evolving RNA are normally able escape pressure treatments single or multiple drugs.