Earlier initiation of enteral nutrition is associated with lower risk of late-onset bacteremia only in most mature very low birth weight infants.

摘要: To examine the temporal relationship between early enteral nutrition (EN) and coagulase-negative staphylococcal (CoNS)-related late-onset bacteremia (LOB) in very low birth weight (VLBW) neonates. Multivariate analyses performed on a large retrospective cohort of neonates admitted to tertiary care neonatal unit. Due predominance particular timing CoNS, LOB occurred mostly during critical period peaking at 9 days age. This also corresponded gestational maturation-dependent breakpoint time achieve full EN, associated with significant reduction incidence (adjusted OR 0.15; 95%CI [0.10–0.20]; P<0.05). In subgroup analyses, more ‘mature’ (i.e. ⩾28 <32 weeks) preterm reached EN before this consequently, earlier group was shorter duration PN reduced CoNS bacteremia. contrast, most ‘immature’ <28 generally received beyond therefore, did not appear benefit from initiation EN. Even though usually initiated when formula milk used as complement breast-milk, practice any groups tested. A observed only mature VLBW who achieved second-week life for These results provide important endpoints future trials evaluating changes nutritional interventions potentially effective reducing LOB.