Depression in context of low neuroticism is a risk factor for stroke: A 9-year cohort study

摘要: Objective: Depression predicts stroke; however, meta-analyses show significant heterogeneity. We hypothesize that the risk of depression on incident stroke is conditional upon relative contribution vascular disease and neuroticism in underlying pathways to a specific patient. examined whether increases persons with low without preexisting cardiac disease. Methods: This was population-based cohort study 9-year follow-up (n = 2,050; ≥55 years, 52% female). The incidence determined by self-report data as well from general practitioners death certificates. Neuroticism measured using Dutch Personality Questionnaire Center for Epidemiologic Studies–Depression scale. All were analysed Cox proportional hazards regression. Results: A total 117 cases occurred during follow-up. Among history 401), predicted independent level hazard ratio (HR) 1.05 (95% confidence interval [CI] 1.01–1.10) ( p 0.02). In 1,649), interacted significantly predicting 0.028). Stratified analyses showed those neuroticism, HR CI 1.00–1.09) 0.033), but not high 1.01 0.96–1.05) 0.82). Conclusions: preexistent disease, only predictive future absence neuroticism. might be explained hypothesis late-life context marker subclinical