The Genomes of Rotaviruses Isolated from Chronically Infected Immunodeficient Children
作者： S. Pedley , F. Hundley , I. Chrystie , M. A. McCrae , U. Desselberger
DOI: 10.1099/0022-1317-65-7-1141
关键词: Genome 、 Severe combined immunodeficiency 、 Immunodeficiency 、 RNA 、 RNA silencing 、 Virology 、 Concatemer 、 Rotavirus 、 Complementary DNA 、 Biology
摘要: Summary Abnormal RNA migration profiles were found in numerous rotavirus samples from two chronically infected children suffering severe combined immunodeficiency. In both cases additional bands consisting of dsRNA migrating between segments 1 and 7, one case segment 11 was lost the profile. Hybridization studies using segment-specific cloned cDNA probes indicated that some had sequence homologies with normal segments. most these sequences derived genome lower molecular weight by formation covalently linked concatemers.
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