Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer.

摘要: Blood vessel density is a prognostic indicator of multiple tumor types. Recently, it has been established that tumor-associated blood vessels express elevated levels integrin alpha(v)beta3. In fact, there evidence alpha(v)beta3 identifies the most proliferative endothelial cells within human breast carcinomas. Therefore, we evaluated cancer tissue in terms both and expression. We found antibody LM609 to preferentially stains small caliber. Furthermore, comparative studies between anti-CD31 antibodies on normal indicate very low weak expression was tissue, whereas CD31 antigen expressed almost all vasculature. Indeed, significantly higher tumors patients with metastasis than those without metastasis. series 197 consecutive invasive long follow-up, vascular "hot spots" be significant factor predictive relapse-free survival node-negative node-positive patients. These findings support contention angiogenesis plays critical role progression suggest an cell marker value potential usefulness as target for specific antiangiogenic therapy.