Generalizing Longitudinal Age Effects on Brain Structure - A Two-Study Comparison Approach.
作者： Katrin Amunts , Susan Mérillat , Christiane Jockwitz , Lutz Jäncke , Franziskus Liem
DOI: 10.3389/FNHUM.2021.635687
关键词: Demography 、 Independent samples 、 Sample (statistics) 、 Cognition 、 Covariate 、 Medicine 、 Healthy aging 、 Normal aging
摘要: Cross-sectional studies indicate that normal aging is accompanied by decreases in brain structure. Longitudinal studies, however, are relatively rare and inconsistent regarding their outcomes. Particularly the heterogeneity of methods, sample characteristics high inter-individual variability older adults prevent deduction general trends. Therefore, current study aimed to compare longitudinal age-related changes structure (measured through cortical thickness) two large independent samples healthy (n = 161 each); Healthy Aging Brain (LHAB) database project at University Zurich, Switzerland, 1000BRAINS Research Center Juelich, Germany. Annual percentage revealed stable slight thickness over time. After correction for major covariates, i.e., baseline age, sex, education, image quality, differences were only marginally present. Results suggest trends across time might be generalizable samples, assuming same methodology used, similar
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