IL-27 enhances the survival of tumor antigen-specific CD8+ T cells and programs them into IL-10-producing, memory precursor-like effector cells.

作者: Zhenzhen Liu , Jin-Qing Liu , Fatemeh Talebian , Lai-Chu Wu , Shulin Li

DOI: 10.1002/EJI.201242930

关键词: Molecular biologyImmunotherapyBiologyCTL*EffectorCell biologyCD8Precursor cellCytotoxic T cellTumor antigenInterleukin 10

摘要: … Since IL-27 directly stimulates CD8 + T-cell differentiation and promotes CTL IL-10 production, we hypothesize that these functions of IL-27 are involved in IL-27-mediated antitumor …

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